REASONS TO REINFORCE EXISTING PREVENTION STRATEGIES
Reasons to Reinforce Existing Prevention Strategies [checklist value="Social distancing (means 6 feet apart)|Stay home (especially if you are sick)|Hand washing (wet, lather, scrub 20 seconds, rinse, dry)|Cough etiquette|Avoid touching your face|Clean surfaces that are frequently touched (dilute bleach or 70 percent alcohol solutions)|Maintain or improve your physical and emotional well-being (diet, exercise, mindfulness, limit internet and other screentime)"] Vaccine Development Takes Time. [checklist value="Phases of vaccine development which historically took several years|Phase 1 - 20 to 100 healthy volunteers to determine if vaccine is safe, seems to work, and evaluate for side effects|Phase 2 - several hundred volunteers to evaluate for short term side effects and evaluate immune response to vaccine|Phase 3 - hundreds or thousands of volunteers to evaluate safety and effectiveness"] Vaccine Development for CORONAVIRUSES Faces Several Challenges. [checklist value="For mucosal infections, natural infection does not necessarily prevent subsequent infection|The propensity of the viruses to recombine may pose a problem by rendering the vaccine useless and potentially increasing the evolution and diversity of the virus in the wild|It has been shown in Feline Infectious Peritonitis Virus (FIPV) that vaccination with S protein leads to enhanced disease (so utilizing the coronavirus's familiar corona of 'spikes' may be a problem."] Vaccines Are Tools to Prevent a Pandemic; There Are other Weapons to Fight Disease. [checkbox memo="display/hide references" name="footnotes" value=""][conditional field="footnotes" condition="(footnotes).is('')"] references: [link url="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369385/" memo="#1"] Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol. 2015;1282:1–23. doi:10.1007/978-1-4939-2438-7_1 [link url="https://www.cdc.gov/vaccines/parents/infographics/journey-of-child-vaccine.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fvaccines%2Fparents%2Finfographics%2Fjourney-of-child-vaccine-text.html" memo="#2"] The Journey of Your Child’s Vaccine. https://www.cdc.gov/vaccines/parents/infographics/journey-of-child-vaccine.html Accessed March 21, 2020. [link url="https://www.cdc.gov/coronavirus/2019-ncov/prepare/prevention.html" memo="#3"] How to Protect Yourself. https://www.cdc.gov/coronavirus/2019-ncov/prepare/prevention.html Accessed March 21, 2020.[/conditional]
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